Introduction: The use of human samples in genomic research has increased ethical debate about informed consent (IC) requirements and the information that subjects should receive regarding the results of the research. However, there are no quantitative data regarding researchers’ attitudes about these issues. Methods: We present the results of a survey of 104 US and 100 Spanish researchers who had published genomic epidemiology studies in 61 journals during 2006. Results: Researchers preferred a broader IC than the IC they had actually (...) obtained in their published papers. US authors were more likely than their Spanish colleagues to support obtaining a broad IC, covering either any future research project or any projects related to a group of diseases (67.6% vs 43%; adjusted OR = 4.84, 95% CI, 2.32 to 10.12). A slight majority of researchers (55.8%) supported informing participants about individual genomic results only if the reliability and clinical validity of the information had been established. Men were more likely than women to believe that patients should be informed of research results even if these conditions were not met (adjusted OR = 2.89, 95% CI = 1.46 to 5.72). Conclusions: This study provides evidence of a wide range of views among scientists regarding some controversial ethical issues related to genomic research, suggesting the need for more study, debate and education. In the interim, journals might consider including the investigators’ policies regarding these ethical issues in the papers they publish in the field of genomic epidemiology. (shrink)

Enhancing the quality of learning opportunities for students with disabilities and the learning level attained is a pending challenge. This challenge is especially relevant in the context of special schools, where the learning possibilities derived from interactions with others is limited. However, providing these students with a sufficient level of instrumental learning, such as literacy, and communicative and reasoning abilities is crucial for their subsequent educational and social opportunities. In this case study we analyse a special school that has implemented (...) Dialogic Literary Gatherings with their students as a means to increase learning interactions within the group around the reading and debate of classical books. Semi-structured interviews were conducted with the school principal and with a teacher of the transition to adult life course, and two focus groups were conducted with teachers–one with primary education teachers and one with secondary education teachers–and two focus groups with students–one with primary education students and one secondary education and transition to adult life students–. On the one hand, results show the characteristics of the Dialogic Literary Gatherings that allowed these students to participate and learn. On the other hand, several improvements have been observed. First, regarding instrumental learning, students increased their motivation for reading, and improved their communicative and reasoning abilities and in their reading proficiency. Second, regarding students' behavior, conflict has reduced, solidarity attitudes have increased, and they have acquired dialogic and argumentative habits. Finally, at the emotional level, they gained self-esteem and confidence and feel more empowered to make their voice heard. (shrink)

El objetivo de este trabajo es realizar una retrospectiva de 15 años (2004-2019) sobre la evolución de las propuestas de trabajo, líneas de investigación y docencia que, con respecto a la enseñanza de las Ciencias Sociales con perspectiva de género, se ha desarrollado en nuestro contexto y su transferencia a las aulas de educación obligatoria, bachillerato y universidad. Se reflexiona sobre el trabajo realizado, el contexto actual y las líneas futuras.

La presente contribución atiende a la interpretación por parte de Heidegger de la dualidad planteada expresamente por Kant de facultades cognoscitivas y sus respectivos tipos específicos de representación. Intentará mostrar cómo su interpretación fenomenológica da cuenta de esta cooriginariedad de sensibilidad y entendimiento y puede incluso –en un sentido bien determinado– legitimarla. Para ello enfoca su interés en el posicionamiento crítico de Heidegger frente a la lectura neokantiana de este elemento doctrinal de la filosofía transcendental de Kant.

Vaccines represent preventative interventions amenable to immunogenetic prediction of how human variability will influence their safety and efficacy. The genetic polymorphism among individuals within any population can render possible that the immunity elicited by a vaccine is variable in length and strength. The same immune challenge (virus and/or vaccine) could provoke partial, complete or even failed protection for some individuals treated under the same conditions. We review genetic variants and mechanistic relationships among chemokines, chemokine receptors, interleukins, interferons, interferon receptors, toll‐like (...) receptors, histocompatibility antigens, various immunoglobulins and major histocompatibility complex antigens. These are the targets for variation among macrophages, dendritic cells, natural killer cells, T‐ and B‐lymphocytes, and complement. The technology platforms (mRNA, viral vectors, proteins) utilized to produce vaccines against SARS‐CoV‐2 infections may each trigger genetically distinct immune reactogenic profiles. With DNA biobanking and immunoprofiling of recipients, global COVID‐19 vaccinations could launch a new era of personalized healthcare. (shrink)

ABSTRACTPolitical actors use metaphor in their speeches in order to frame political issues [Charteris-Black, J.. Politicians and rhetoric: The persuasive power of metaphor. Basingstoke: Palgrave Macmillan]. If they succeed in imposing a particular frame, especially when there is no agreement on the definition of certain political issues, this can become the prevailing way for referring to that issue [Semino, E.. Metaphor in discourse. Cambridge: Cambridge University Press]. In this research, we argue that this was the case for the metaphor of (...) the JOURNEY in the Catalan political conflict during electoral periods. To that end we use Critical Metaphor Analysis [Charteris-Black, J.. Corpus approaches to critical metaphor analysis. Basingstoke: Palgrave Macmillan] to analyse televised campaign ads from the last three elections for the Parliament of Catalonia – from 2010, 2012, and 2015 – in order to identify how political actors’ use metaphors to talk about the Catalan political situation during these years and to verify if JOURNEY metaphor resulted into the dominant narrative. The results show that the political situation has been conceptualized in terms of a ‘process en route,’ although the narratives generated by the political actors that shaped that discourse differ. (shrink)

This introduction to the Journal of Business Research special issue on anti-consumption briefly defines and highlights the importance of anticonsumption research, provides an overview of the latest studies in the area, and suggests an agenda for future research on anti-consumption.

Genomic research results and incidental findings with health implications for a research participant are of potential interest not only to the participant, but also to the participant's family. Yet investigators lack guidance on return of results to relatives, including after the participant's death. In this paper, a national working group offers consensus analysis and recommendations, including an ethical framework to guide investigators in managing this challenging issue, before and after the participant's death.

En este artículo se va a estudiar la relación que existe en Leibniz entre verdad eterna, razón soberna y libertad divina. Si la razón soberana se puede constituir como juez supremo es porque contiene unas verdades eternas que Dios no ha creado sino que pertenecen a la misma esencia divina. Estas verdades en cuanto esencias, tienden a existir en la medida de su perfección, pero no existirán necesariamente, sino que Dios las pone en la existencia mediante un acto libre. Ante (...) la posibilidad de pensar que Dios pudiera verse obligado a elegir aquello que mejor, Leibniz sostendrá que Dios elige crear siempre lo mejor en un primer decreto máximamente libre y voluntario. de este modo el resto de sus elecciones son también máximamente libres y racionales. (shrink)

Returning genomic research results to family members raises complex questions. Genomic research on life-limiting conditions such as cancer, and research involving storage and reanalysis of data and specimens long into the future, makes these questions pressing. This author group, funded by an NIH grant, published consensus recommendations presenting a framework. This follow-up paper offers concrete guidance and tools for implementation. The group collected and analyzed relevant documents and guidance, including tools from the Clinical Sequencing Exploratory Research Consortium. The authors then (...) negotiated a consensus toolkit of processes and documents. That toolkit offers sample consent and notification documents plus decision flow-charts to address return of results to family of living and deceased participants, in adult and pediatric research. Core concerns are eliciting participant preferences on sharing results with family and on choice of a representative to make decisions about sharing after participant death. (shrink)

El confinamiento 2020 – 21 obligó a la humanidad a adaptarse al nuevo modo de vida y creación de nuevos escenarios con tecnologías que transformaron espacios físicos y tradicionales de enseñanza, abruptamente reemplazados por escenarios virtuales. Este estudio transversal, exploratorio y descriptivo, realizado aplicando formularios y entrevistas semiestructuradas a estudiantes y docentes de Diseño UCTemuco; recogió la percepción e implementación de la docencia a distancia realizada y evaluó el retorno presencial. Levantamos fortalezas, dificultades y oportunidades en esta nueva forma de (...) enseñanza que se nos desafía interpelándonos a raíz de aprendizajes adquiridos, emergentes metodologías, plataformas educativas y políticas de internacionalización institucionales. (shrink)

In this paper we deal with some new axiom schemes for Peano's Arithmetic that can substitute the classical induction, least-element, collection and strong collection schemes in the description of PA.

This study aims to diagnose how the cinema of cruelty has been inserted into mainstream culture through the current streaming series, analysing the elements of the eroticism of perversity and the c...